Now that it's been 24 hours since the Methotrexate was given, they are giving Talitha Leucovorin to help her clear the Methotrexate from her system and recover from its effects. In order for them to continue with the other therapy drugs (see yesterday's update), her Methotrexate levels in the body must subside to 0.1. They will be doing blood draws every 24 hours to see where her level is. Her level tonight is 17.85.
They seem to have the nausea under control for now. The biggest challenge is getting sleep. Due to kidney damage risk, they must keep substantial levels of fluid running through her system and confirm every two hours that her urine output is sufficient. Talitha is not yet at the level of exhaustion where she will sleep through a diaper change but I imagine it must be getting close.